A recently published study microbiome Changes in the intestinal, urinary, and salivary microbiomes were shown to be associated with kidney stone formation.1
The findings also suggest that because kidney stone patients have an increased number of antibiotic resistance genes, they are exposed to more antimicrobial drugs.
In the study, researchers compared the three microbiomes of 83 kidney stone patients and 30 healthy controls. The patient with kidney stones had not taken antibiotics in the past 90 days and underwent stone removal surgery at St. Joseph’s Healthcare of London, Ontario.
Our test, called shotgun metagenomic sequencing, allows us to discover which bacteria are present in the gut and the genetic capabilities of those bacteria or their functions. We also performed simpler sequencing on oral and urine samples, lead author Kait Al, Ph.D., explained in a press release about the study results.2 Al is a postdoctoral fellow at the Schulich School of Medicine and Dentistry at Western University in London, Ontario.
Overall, the researchers observed that health-related markers, such as vitamin production, butyrate biosynthesis, and core beneficial taxa, were affected by virulence factors, antimicrobial resistance, and gut microbiota in the stone formers’ urine and gut microbiota. replaced by sexual elements and pathogenic bacteria.
The urine samples in the study showed a greater abundance of sequence variants, e.g. Gardnerella., Macrococcus. , and wild flowers Compared with stone formers, among healthy controls, Lactobacillus jensenii It is more abundant in stone tools. Levels of vitamin B6 biosynthesis were also increased in urine samples from stone formers compared with healthy controls, while levels of vitamin B12 biosynthesis, butyrate biosynthesis, and several basic bioenergetic enzyme pathways were significantly decreased.
Saliva samples from both cohorts showed a greater diversity of stone formers compared with healthy controls.
Looking at the gut microbiome, the abundance of 82 bacterial taxa differed between stone formers and controls. Overall, the two groups differed in alpha diversity, relative taxonomic composition, functional potential, and overall network structure.This includes an enrichment of numerous pathogenic and disease-associated microorganisms among stone formers and a decrease in unclassified taxa from this phylum Bacillus and health-relatedFusarium prausnitziiaccording to the author.
Other alterations with stone development potential include abundant Desulfovibrio spp., Important characteristics of stone formers based on self-analysis, andflavone proton.Notably, the researchers did not find any significant differences maltogenes Abundances between the two cohorts, showing no significant role of oxalate degradation in stone formation.
The findings also suggest that because kidney stone patients have an increased number of antibiotic resistance genes, they are exposed to more antimicrobial drugs.
“Not only did we find that kidney stone patients have unhealthy microbiota, including gut microbiota that are more likely to excrete toxins into the kidneys, but they were also found to be resistant to antibiotics,” Jeremy Burton, Ph.D., MS, said in a press release. Resistant to antibiotics. .2 Burton is a Lawson Scientist and Research Chair in Human Microbiome and Probiotics at St. Joseph’s Medical Center in London and an associate professor of microbiology and immunology at the Schulich School of Medicine and Dentistry in London, Ontario.
While the authors note that further research is needed, they say their findings show the importance of maintaining a healthy microbiome.
They concluded that if the diversity and robust functional potential of the healthy human microbiome are repeatedly attacked by an average Westernized lifestyle through antibiotic exposure, diet and other environmental factors, kidney stone prevalence will continue to increase. To prevent cyclic recurrence of this disease, future treatment of kidney stones should include the prevention of microbiome disruption and the use of drugs to subsequently restore homeostasis.1
refer to
1. Al KF, Joris BR, Daisley BA, et al. Alterations in the microbiota at multiple sites are hallmarks of kidney stone formation. microbiome. 2023 Nov 25;11(1):263. doi:10.1186/s40168-023-01703-x
2. New research reveals link between microbiome and kidney stones. Press Releases. Lawson Health Research Institute. December 20, 2023. Viewed December 21, 2023. https://www.newswise.com/articles/new-study-sheds-light-on-the-connection-Between-the-microbiome-and-kidney -stones
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